The paper describes preconditions for interregional energy production cooperation between the Republic of Komi, the North-Western and the Ural Federal Districts, based on an analysis of the resource base, production dynamics, processing of fuel and energy resources and transportation of oil and gas. Types of energy production cooperation specific for the regions in question have been identified; these types represent an essence for establishment of a large macro-region within the framework of the territories in question. A prospect of their extension is demonstrated.