The article deals with the formation of a region-level system of management for foreign economic relations in the Republic of Belarus. It emphasizes the importance of socially oriented foreign economic efforts for regional development. The article notes shortcomings in the current regulations that limit involvement of local authorities in efforts to encourage regions' integration into the world economy. It substantiates fundamental approaches to the formation of a mechanism for managing international economic relations at a regional level and suggests methods based on specific features of a managed region. The author stresses the need for institutional support of a region's efforts to establish and consolidate international economic ties. The proposed solutions imply improvements to the system of local government and local self-government in the Republic of Belarus.